Treatment strategies , systemic manifestations and biomarkers in airway diseases

printing supported by . Visit Chiesi at Stand D.30 TUESDAY, SEPTEMBER 27TH 2011 value of C5 to predict MI on the efficacy of BDT on cough was solution number of 4.5 (2.8 mmol/L) with a sensitivity of 0.81 and specificity of 0.72. Conclusions: Measurement of C5 may be useful for predicting efficacy of BDT on chronic non-productive cough, in other words for diagnosis of CVA. P4056 Systemic inflammation in COPD: Is there a link with body composition? Adèle Lo Tam Loi1, Susan Hoonhorst2 , Nick ten Hacken2, Jan-Willem Lammers1, Leo Koenderman1. 1Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands; 2Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands Introduction: COPD is characterized by a low grade systemic inflammation which has an effect on body composition. We examined the relationship between systemic inflammation and body composition using the Body Mass Index (BMI) and Fat Free Mass Index (FFMI). Methods: A cohort of 37 stable COPD patients (GOLD I-IV) was included. BMI was calculated as weight/height2 and the FFMI as fat free mass/height2. Systemic inflammation was visualized by expression of activation markers on peripheral blood neutrophils using flow cytometry. Results: The responsiveness of neutrophils for formyl peptides (like fMLF) is one of the most sensitive markers for detecting in vivo activation of neutrophils. Peripheral blood neutrophils are less responsive for fMLF under conditions of systemic inflammation, which is associated with disease severity. This responsiveness in the context of expression of CD11b and the active form of FcγRII was positively correlated with BMI (Table 1). We also found that CCR3, a marker mainly expressed on pulmonary neutrophils correlated with BMI. In addition, a positive correlation (Table 1) between FFMI and BMI was found in COPD patients. Table 1. Indices of systemic inflammation correlate with a low BMI Correlation between BMI Sig (2-tailed)