Detection of PrPSc in peripheral tissues of clinically affected cattle after oral challenge with bovine spongiform encephalopathy

Received 6 July 2012 Accepted 20 August 2012 Institute for Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany Virus and Prion Research Unit, National Animal Disease Center, ARS, USDA, PO BOX 70 Ames, IA 50010, USA Department of Veterinary Sciences and Molecular Biology, University of Wyoming, MICRO/Molecular Biology, 1000 E. University Avenue Laramie, Wyoming, WY 82071, USA Kansas State University, College of Veterinary Medicine, K224B Mosier Hall, Manhattan, KS 66506, USA Ernst-Moritz-Arndt University, Zoological Institute, Animal Physiology and Biochemistry, Biotechnikum, Walther-Rathenau-Strasse 49a, 17489 Greifswald, Germany