Souborný referát Molecular basis of hypodontia . A review of the literatuře

Hypodontia is the most prevalent hereditary dental disorderin the human population. Tooth numbers reduced in patients with Rieger syndrome, anhidrotic ectodermal dysplasia or Witkop tooth-and-nail syndrome. These syndromes result from defects in key regulatory genes (Pitx2, Eda orMsxi) mediating common molecular pathways controlling epithelio-mesenchymal signalling. Additionally to syndromic forms, hypodontia onen occurs as an isolated hereditary disorder. However, mutations in only three genes (Pax9, Msxl, Axin2) háve been associated with isolated forms of hypodontia until now, and the molecular basis of hypodontia is in the majority of cases notknown. Identification of other genes mutated in patients with hypodontia is a great challenge forcurrent research (Ortodoncie 2007,16, No. 1, p. 33-39). Klíčová slova: Hypodoncie, nesyndromické ageneze zubů, syndromické ageneze zubů