Targets for treatment of dystonia caused by several etiologies . Meta analysis

Introduction: To use a meta-analysis on all reported cases of deep brain stimulation (DBS) for dystonia to reevaluate the good effect using the GPi as a target, which factors significant influence outcome related to the target. The Burke-Fahn-Marsden (BFM) movement scale, the most reported measure, was chosen as the primary outcome measure for this analysis. Material and Methods: Computerized MEDLINE searches on English literature search identified 137 patients who underwent BBS for dystonia in 24 studies that had individual BFM scores. The study was done with statistical analysis by intention to treat. Statistical analysis was made with a significant pvalue of 0.05. For the comparison of preand postoperative scores, a test Wilcoxon signed was used. Results: The mean BFM percentage change (improvement in postoperative score from baseline) was 46.3%(range 34% to 100%). At last follow-up, disease severity and the degree of disability and pain on the BFM were significantly improved by 70.4%, and 67.8%, respectively (p < 0.05, Wilcoxon signed-rank test). Significantly better outcomes