P0166 Correlation of gliotoxin and bis(methylthio)gliotoxin production with Aspergillus spp viability during voriconazole treatment

Gliotoxin (GT) and bis(methylthio)gliotoxin (bmGT) are secondary metabolites produced by Aspergillus spp. Both molecules had been purposed as diagnostic biomarkers of invasive aspergilosis. Moreover, bmGT shows a potential utility as prognostic marker: its serum presence correlates with clinical severity whereas its clearance could correlate with antifungal effectiveness. The aim of this study was to assess the effect of voriconazole within Aspergillus spp viability and its ability to produce GT and bmGT.