Clinical Trials of New Permethrin Preparation Efficacy on Sarcoptic Mite Infestation in Sheep and Rabbits

The present study was conducted to evaluate the efficacy of topically applied Permethrin proniosome (PP) Emulgel 5%, (PP) Powder 5% and compare it with commercially available Permethrin lotion 5% for treatment of naturally infested sarcoptic mange in sheep and rabbits. A total of 10 rabbits and 2 sheep were enrolled in this study, diagnosis of naturally infested sarcoptic mange in animals was made by identifying skin scrapings and all cases were severely infested with relevant significant clinical signs of scabies. Evaluation of clinical signs suggested that faster complete clinical cure of lesions of infested animals used topically applied (PP) Emulgel was obvious than animals treated with 5% permethrin lotion while (PP) topical powder was not effective as scabicide. In conclusion, the use of proniosome dispersed in Emulgel base which act as penetration enhancer could be used together propelarly as good drug delivery system with Permethrin as a new era for treatment of Sarcoptes scabiei in sheep and rabbits.