The novel γ secretase inhibitor MRK-560 reduces amyloid plaque deposition without evidence of Notch-related pathology in the Tg 2576 mouse

Jonathan D. Best,David W. Smith,Michael A. Reilly, Ruth O’Donnell, D. Lewis, Semantha Ellis,Neil Wilkie,Thomas W. Rosahl, Philippe A. Laroque, Christine Boussiquet-Leroux,Ian Churcher,Timothy Harrison

semanticscholar（2006）

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摘要

Department of In Vivo Neuroscience (J.D.B., J.R.A.), Department of Molecular & Cellular Neuroscience (D.W.S., R.O., H.D.W., S.E., N.W., T.W.R., M.S.S.), Department of Chemistry (M.A.R., I.C., T.H.), Merck Sharp & Dohme, Neuroscience Research Centre, Eastwick Road, Harlow, Essex, CM20 2QR, UK. Department of Safety Assessment (C.B-L, P.A.L) Merck Sharp & Dohme Research Centre, Chibret, Route de Marsat, Riom, 63963 Clermont-Ferrand, France JPET Fast Forward. Published on November 10, 2006 as DOI:10.1124/jpet.106.114330

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