Chronic myelogenous leukemia cells remodel the bone marrow niche 1 via exosome-mediated transfer of miR-320 2

Chronic myelogenous leukemia cells remodel the bone marrow niche 1 via exosome-mediated transfer of miR-320 2 Xiaotong Gao, Zhuo Wan, Mengying Wei, Yan Dong, Yingxin Zhao, Xutao Chen, 3 Zhelong Li, Weiwei Qin, Guodong Yang, Li Liu 4 Department of Hematology, Tangdu Hospital, Fourth Military Medical University, Xi’an, 5 710038, People’s Republic of China. 6 State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, 710032, 7 People’s Republic of China. 8 Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 9 Xi’an, 710032, People’s Republic of China. 10 Department of Implantation, School of Stomatology, Fourth Military Medical University, 11 Xi’an, 710032, People’s Republic of China. 12 Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical 13 University, Xi’an, 710038, People’s Republic of China. 14 # These authors contributed equally to this work. 15