Speciated Arsenic Analysis in Wine Using HPLC-ICP-QQQ Validation of an extended FDA Elemental Analysis Manual method

In 2013, the US Food and Drug Administration (FDA) released Elemental Analysis Manual (EAM) Method §4.10. The method describes the Determination of Four Arsenic Species in Fruit Juice using High-Performance Liquid ChromatographyInductively Coupled Plasma-Mass Spectrometry [1]. To extend the method to include wine, a multi-laboratory validation (MLV) of the method was carried out with three US-based laboratories sharing their data [2]. The data shown in this application note is supplementary to the published data. In addition to the paper, this note includes long term stability of the method, and extended quantitative analysis of five commercially available wines. The method required separation and analysis of all target species. This approach differs from another Agilent application note, which focused on the development of a fast method for inorganic arsenic (iAs) [3].