Changes in the serum ALT, ALP and Bilirubin level after laparoscopic surgery in Cholelithiasis

Cholelithiasis is one of the significant diseases in the world and one of the most common diseases presenting to emergency department of the hospitals. Laparoscopic surgery is an important treatment for the cholelithiasis and its effectiveness is measured by analyzing the pre and post surgery levels of serum ALT, ALP and bilirubin.The present study was designed to estimate the changes of ALT, ALP and bilirubin before and after Laparoscopic surgery. This is a retrospective study in which 100 patients from different hospital were enrolled. A venous blood pre and post surgery (24 hours) was collected for alanine aminotransferase (ALT), alkaline phosphatase (ALP) and Bilirubin. Alanine aminotransferase (ALT), alkaline phosphatase (ALP) and Bilirubin were measured by ARCHITECT c4000 Clinical Chemistry (Abbott USA).The data was analyzed using Statistical Package for the Social Sciences (SPSS Version 13.0, Chicago, IL).In the study group of 100, 49 were male and 51 were female. The male female ratio was approximately same (1:1). The patients were diagnosed for cholelithiasis by ultrasonography, biochemical analysis of the liver and clinical investigation. ALT, ALPand Bilirubin were found high before surgery. Theseanalytes were decrease significantly after surgery. It has been observed that a significant decrease observed in the patients ALP value (p = 0.001) while AST (p = 0.052) and bilirubin (p = 0.56) have no significant decreased after surgery. A significant decline in the ALP was observed while decline in the ALT and bilirubin was observed but not significant statistically.