Synthesis of icosadeuterio-benzopinacol ( Benzopinacol-d 20 )

Received: 06 March 2019 Received in revised: 23 May 2019 Accepted: 23 June 2019 Available online: 20 July 2019 DOI: 10.26655/JMCHEMSCI.2020.1.4 This work reports on synthesis of high yield (92%) of isosadeuteriobenzopinacol (benzopinacol-d20) via photo-reductive dimerization of benzophenone-d10. The latter compound was obtained using an improved method to achieve a material with high isotopic purity (> 99%). This material can be served for calibration of mass spectrometric assays. In this study, it was also observed that benzophenone-d10 reacts faster than its natural abundance counterpart. However, elucidating the origin of this phenomenon will require additional work.