1 Cdk 1-mediated Phosphorylation of Receptor Associated Protein 80 ( RAP 80 ) Serine 677 Residues Modulate DNA Damage-induced G 2 / M Checkpoint and Cell Survival

Background: RAP80, a member of the BRCA1-A complex, is crucial in cell cycle checkpoint and DNA damage repair. Results: RAP80 phosphorylation by Cdk1 is important for sensitivity to ionizing radiation and G2/M checkpoint control. Conclusion: Cdk1-mediated RAP80 phosphorylation is important for the DNA damage response. Significance: The findings provide new implications for the interplay of the DNA damage signaling pathway and RAP80 phosphorylation.