1 Characterization of the gut-associated cathepsin D hemoglobinase from the tick Ixodes ricinus ( Ir CD 1 )

Daniel Sojka, k Franta,Helena Frantová,Pavla Bartošová,Martin Horn,Jana Váchová,Anthony J. O’Donoghue,Alegra A. Eroy-Reveles,Charles S. Craik,Giselle M. Knudsen,Conor R. Caffrey,James H. McKerrow,Michael Mareš,Petr Kopá, Ek

semanticscholar（2012）

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摘要

Background: Aspartic peptidase activity initiates a multienzyme hemoglobinolysis inside tick guts. Results: IrCD1 is a structurally unique hemoglobinolytic cathepsin D that is upregulated in tick gut cells during feeding. Conclusion: IrCD1 is the major intestinal aspartic peptidase of I. ricinus. Significance: Biochemical and functional characterization of IrCD1 completes our knowledge on initial host hemoglobin degradation inside tick gut cells.

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