Synthesis of novel bifunctional bisphosphonates
semanticscholar(2014)
摘要
Bisphosphonates (BPs) are synthetic molecules containing a P-C-P backbone and are very well known class of organophosphorus compounds which have many applications in different fields of industry. BPs have high affinity for hydroxyapatite (HAP), which is the main mineral found in bones, and they can chelate several metal ions, such as Mg(II), Ca(II), and Fe(II). BPs are easily taken up by the bone tissue where they can prevent the resorption of bone. This makes them crucial to be used in the treatment of diseases related with increased bone resorption, for instance osteoporosis. The aim of the current research is to show an approach to chemistry underlying the properties of novel chealating agents with BP and polyamine (PA) moieties. In this study, two novel BP-PA conjugates were prepared and characterized by NMR method. This thesis is a part of the investigations based on BPs and their functions in pharmaceutical chemistry field.
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