DEXþHF induced sex-specific alterations of protein profiles in offspring kidneys. Application of the quantitative proteomics techniques described herein may provide some candidate proteins for future studies. Identification of the underlying sex-specific mechanisms could provide novel intervention t

INTRODUCTION AND AIMS: Excessive intake of fructose causes a variety of adverse conditions including obesity, hepatic steatosis, insulin resistance, and uric acid overproduction. Hypertension is the most common and significant clinical concern related to high fructose intake. Recent works revealed the activation of renal sodium-hydrogen exchanger 3 (NHE3) causing sodium retention, which may be a result of fructoserelated ATP consumption; however, this has not been directly demonstrated. Here we investigated the NHE3 activation and ATP consumption in rats fed a high-fructose diet.