1 A Small Molecule that Mimics the BB-loop in the Toll / IL-1 Receptor Domain of MyD 88 Attenuates Staphylococcal Enterotoxin B Induced Pro-inflammatory Cytokine Production and Toxicity in Mice

A Small Molecule that Mimics the BB-loop in the Toll/IL-1 Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B Induced Pro-inflammatory Cytokine Production and Toxicity in Mice Teri L. Kissner, Lionel Moisan, Enrique Mann, Shahabuddin Alam, Gordon Ruthel, Robert G. Ulrich, Mitra Rebek, Julius Rebek Jr. , and Kamal U. Saikh From Department of Immunology, Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702; The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 Running head: Synthetic BB-loop mimetics of MyD88 inhibit SEB intoxication Address correspondence to: Kamal U. Saikh, Ph. D, 1425 Porter Street, Frederick, MD 21702. Fax: (301) 619-6724; E-mail: kamal.saikh@amedd.army.mil