IFN-l 4 desensitizes the response to IFNa treatment in chronic hepatitis C through long-term induction of USP 18

Received 10 March 2016 Accepted 10 June 2016 Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, PR China School of Life Sciences and Technology, Shanghai Tech University, Shanghai 200031, PR China Hepatology Section, First Hospital, University of Jilin, Changchun 130021, Jilin, PR China Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai, PR China