Biochemical characterization of GSK 1070916 , a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time 1

Kelly ANDERSON*, Zhihong LAI*, Octerloney B. MCDONALD†, J. Darren STUART‡, Eldridge N. NARTEY‡, Mary Ann HARDWICKE§, Ken NEWLANDER‖, Dashyant DHANAK‖, Jerry ADAMS‖, Denis PATRICK§, Robert A. COPELAND*, Peter J. TUMMINO* and Jingsong YANG*2 *Enzymology & Mechanistic Pharmacology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, U.S.A., †Biological Reagents and Assay Development, GlaxoSmithKline, Research Triangle Park, NC 27709, U.S.A., ‡Screening and Compound Profiling, GlaxoSmithKline, Research Triangle Park, NC 27709, U.S.A., §Oncology Biology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, U.S.A., and ‖Oncology Medicinal Chemistry, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, U.S.A.