The Expression and Clinicopathologic Significance of Mir-22 in Gastric Cancer

Objective: To investigate the expression and clinicopathologic significance of miR-22 in human gastric cancer. Methods: Tissue microarray and in situ hybridization were used to detect the expression level of miR-22 in 89 gastric cancer tissues and 41 normal tissues. Results: In situ hybridization showed that the expression level of miR-22 in gastric cancer tissues was significantly down-regulated compared with normal gastric mucosa tissues (P < 0.01), and the expression level of miR-22 in gastric cancer tissues was positively correlated. In 89 cases of gastric cancer, the expression level of miR-22 was negatively correlated with clinical staging and lymph node metastasis (P < 0.01). Conclusion: The expression of miR-22 in gastric cancer was down-regulated and correlated with clinical staging and lymph node metastasis of gastric cancer.