Author's response to reviews Title: The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain Authors:

Brigitte Metzger (brigitte.metzger@crp-sante.lu) Laetitia Chambeau (laetitia.chambeau@crp-sante.lu) Dominique Y Begon (D.Begon@ulg.ac.be) Carlo Faber (Carlo.faber@zitha.lu) Jacques Kayser (grchir@pt.lu) Guy Berchem (Berchem.Guy@chl.lu) Marc Pauly (marc.pauly@crp-sante.lu) Jacques Boniver (j.boniver@ulg.ac.be) Phillippe Delvenne (p.delvenne@ulg.ac.be) Mario Dicato (Dicato.Mario@chl.lu) Thomas Wenner (thomas.wenner@univ-lyon1.fr)