Influence of Caffeine on Pharmacokinetics of Micellar Drug Promethazine in rabbits

Promethazine (PMZ) is an antihistamine drug. It also possesses sedative and neuroleptic properties and is characterized by significant presystem metabolism. Molecules of PMZ have surface active nature and formation of micelles takes place in solution at CMC (4.4×10M). This affects strongly the interaction of PMZ with other drugs. Caffeine (Caff) is a strong stimulator of central nervous system. Stimulation of metabolic processes in different organs and tissues, as well as secretory action of stomach proceed under the influence of Caff. It enters the human organism during consumption of beverages like tea, coffee, Coca-cola and so on. Therefore study of influence of Caff on pharmacokinetics of other drugs is important.