Phosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis.

Journal of Biological Chemistry(2014)

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摘要
The following sentence was incorrect. “Several kinases that are implicated in insulin action were absent, including protein kinase A (PKA), mammalian target of rapamycin, phosphatidylinositol 3-kinase (PI3K), mitogen-activated kinase 3 (MAPK3)/extracellular signal-regulated kinase 1 (ERK1), MAPK1/ERK2, MAP2K1/mitogen-activated protein kinase kinase 1 (MEK1), and MAP2K2/MEK2.” This sentence should be corrected as follows. “Several kinases that are implicated in insulin action were absent, including p70S6K (RPS6KB2), mammalian target of rapamycin, phosphatidylinositol 3-kinase (PI3K), mitogen-activated kinase 3 (MAPK3)/extracellular signal-regulated kinase 1 (ERK1), MAPK1/ERK2, MAP2K1/mitogen-activated protein kinase kinase 1 (MEK1), and MAP2K2/MEK2.” THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 41, p. 28137, October 10, 2014 © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.
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关键词
androgen biosynthesis,human cytochrome p450c17,lyase activity,phosphorylation
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