DOCK 8 functions as an adaptor that links Toll-like receptor – MyD 88 signaling to B cell activation

DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and CD27+ memory B cells were severely reduced in DOCK8-deficient 15H.H.J. and D.R.M. contributed equally to this work. AUTHOR CONTRIBUTIONS H.H.J., D.R.M., E.J, M.J.M., N.R., A.B., I.R., H.B., and M.R. performed the experiments. L.S., S.B, R.W., G.D., M.D., W.A., I.B., S.B., N.K., H.O., A.P., M.K., G.L. and I.R., provided patient blood samples. K.F. and D.G. provided mice. J.M. and L.N. provided advice. S.K, R.C. and T.C. performed DNA sequencing. H.H.J. and R.S.G. wrote the manuscript. COMPETING FINANCIAL INTERESTS The authors declare no competing financial interests. NIH Public Access Author Manuscript Nat Immunol. Author manuscript; available in PMC 2012 December 01. Published in final edited form as: Nat Immunol. ; 13(6): 612–620. doi:10.1038/ni.2305.