Smad 2 disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice

CEREBELLAR DEVELOPMENT AND EARLY POSTNATAL ATAXIA IN MICE Lixiang Wang, Masatoshi Nomura, Yutaka Goto, Kimitaka Tanaka, Ryuichi Sakamoto, Ichiro Abe, Shohei Sakamoto, Atsushi Shibata, Patricio L.M. Enciso, Masahiro Adachi, Keizo Ohnaka, Hisaya Kawate, Ryoichi Takayanagi From the Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan Running title: Role of Smad2 in cerebellar development To whom correspondence should be addressed: Masatoshi Nomura, MD PhD; Tel: +81-92-642-5293; Fax: +81-92-642-5287; E-mail: nomura@med.kyushu-u.ac.jp