Potential of PDL Stem Cells in Periodontal Regeneration- Review

Periodontal regeneration refers to healing after periodontal surgery that result in the restoration of the lost periodontium and attachment apparatus including cementum, alveolar bone and periodontal ligament. Although, regenerative techniques have been available for several years, and some have shown promising results, none of the techniques are without problems and none have proven to be 100% effective. Stem cells are the latest entrant in periodontal regeneration. Amongst which, Dental Mesenchymal Stem Cells are currently the focus of research as these cells can be harvested with considerable ease and are associated with minimal donor morbidity. Periodontal ligament stem cells possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in Periodontal ligament stem cells transplantation. The present review updates the potential of Periodontal ligament stem cells and discusses standard criteria for culture and biological safety for application of Periodontal ligament stem cells.