Intracellular replication of Streptococcus pneumoniae inside splenic m a crophages serves 4 as a reservoir for septicaemia 5 6 7

Giuseppe Ercoli, Vitor E. Fernandes, Wen Y. Chung, Joseph J Wanford, Sarah Thomson, 8 Christopher D. Bayliss, Kornelis Straatman, Paul R. Crocker, Ashley Dennison, Luisa 9 Martinez-Pomares, Peter W. Andrew, E. Richard Moxon, Marco R. Oggioni* 10 11 12 1 Department of Genetics, University of Leicester, UK 13 2 Department of Infection Immunity and Inflammation, University of Leicester, UK 14 3 Hepato-Pancreato-Biliary (HPB) Unit, Leicester General Hospital, University of Hospitals of 15 Leicester, NHS Trust, UK 16 4 Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, UK 17 5 Centre for Core Biotechnology Services, University of Leicester, UK 18 6 School of Life Sciences, Faculty of Medicine & Health Sciences, University of Nottingham, UK 19 7 Department of Pediatrics, University of Oxford, UK 20 21