25-Hydroxy Vitamin D level in Type 2 Diabetics and Non Diabetics : A Comparative Study

Background: Type 2 diabetes mellitus (T2DM) affects about 150 million populations worldwide and this figure is expected to be double in next two decades. Although role of vitamin D deficiency in musculoskeletal diseases are well documented, its connection with other diseases including DM pathophysiology has been implicated. Aim: Therefore, an attempt has been made to measure 25(OH) vitamin D levels in T2DM and non-diabetic population and to determine their relation with glycosylated hemoglobin (HbA1c). Material and methods: In the present study, serum 25(OH) vitamin D and HbA1C levels along with fasting and postprandial plasma glucose levels were measured in 50 diabetic patients and statistically compared with that of age matched 50 non diabetics subjects, served as control by using student’s t test and Pearson correlation coefficient analysis. Results: Serum 25(OH) vitamin D levels were found to be decreased significantly (p<0.001) in T2DM subjects as compared to the control. HbA1c, fasting and post prandial blood sugar levels were increased significantly (p<0.001). In addition, 25(OH) vitamin D level was negatively correlated with HbA1c (p<0.05; r = -0.528) in diabetic patients. Conclusion: On the basis of the present study, we conclude that hyperglycemia is linked with poor vitamin D status and the effects of this deficiency during type 2 diabetes seem to have negative consequences on insulin resistance and glucose homeostasis.