Simulation of midazolam pharmacokinetics after buccal administration

Haiying Zhou,Ke Xu Szeto,Viera Lukacova,Michael B. Bolger,Walter S. Woltosz

semanticscholar（2013）

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摘要

SUMMARY: A physiologically based pharmacokinetic (PBPK) model for simulation of midazolam and its major metabolite 1’-hydroxymidazolam after iv, PO and buccal administration in adult subjects was developed.

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