Cortical Porosity in Type-2 Diabetic Postmenopausal women with and without fragility fractures

The goal of our study was to investigate cortical and trabecular bone structure and strength in T2DM subjects with and without fragility fractures and compare them to age-matched controls with and without osteoporotic fragility fractures. In particular, this study focuses on the cortical porosity-related measurements of the radius and tibia. Using high-resolution peripheral quantitative computed tomography (HRpQCT), the structural differences in the trabecular and cortical regions of these sites were evaluated; in addition micro-finite element analysis (μFEA) was performed in these datasets to compute estimates of bone strength and the distribution of load between cortical and trabecular bone. Findings were compared to Dual-energy X-ray absorptiometry (DXA) measurements of the hip, spine and radius, which served as a standard of reference.