Differential immunodominance hierarchy of CD 8 + T-cell responses in HLA-B * 27

The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05restricted CD8 T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. We studied the impact of the 3 amino acid differences between HLA-B*27:05 and the closely related HLA-B*27:02 on the HIV-specific CD8 T-cell response hierarchy and on immune control of HIV. Genetic epidemiological data indicate that both HLA-B*27:02 and Received 22 September 2017 Accepted 3 November 2017 Accepted manuscript posted online 22 November 2017 Citation Adland E, Hill M, Lavandier N, Csala A, Edwards A, Chen F, Radkowski M, Kowalska JD, Paraskevis D, Hatzakis A, Valenzuela-Ponce H, Pfafferott K, Williams I, Pellegrino P, Borrow P, Mori M, Rockstroh J, Prado JG, Mothe B, Dalmau J, Martinez-Picado J, Tudor-Williams G, Frater J, Stryhn A, Buus S, Teran GR, Mallal S, John M, Buchbinder S, Kirk G, Martin J, Michael N, Fellay J, Deeks S, Walker B, Avila-Rios S, Cole D, Brander C, Carrington M, Goulder P. 2018. Differential immunodominance hierarchy of CD8+ T-cell responses in HLA-B*27:05and -B*27:02-mediated control of HIV-1 infection. J Virol 92:e01685-17. https://doi.org/10.1128/JVI .01685-17. Editor Frank Kirchhoff, Ulm University Medical Center Copyright © 2018 Adland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. Address correspondence to Philip Goulder, philip.goulder@paediatrics.ox.ac.uk. CELLULAR RESPONSE TO INFECTION