Local delivery of anticancer agents or gene therapeutics to lung tumors can circumvent side effects or accumulation in non-target organs

Th is pa pe r h as b ee n pe er -re vi ew ed a nd a cc ep te d fo r p ub lic at io n, b ut h as y et to u nd er go co py ed iti ng a nd p ro of co rr ec tio n. T he fi na l p ub lis he d ve rs io n m ay d iff er fr om th is pr oo f. Multimodal fluorescenceand bioluminescence imaging reveals transfection potential of intratracheally administered polyplexes for breast cancer lung metastases Antonia Geyer, Alexander Taschauer, Fatih Alioglu, Martina Anton, Julia Maier, Elisabeth Drothler, Manuela Simlinger, Sümeyye Yavuz, Haider Sami and Manfred Ogris 1 Laboratory of MacroMolecular Cancer Therapeutics (MMCT), Center of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria