Biomarqueurs du syndrome cardiorénal Biomarkers of cardiorenal syndrome

Complex interactions existing between cardiac and renal diseases led to define 5 types of so-called cardiorenal syndromes. This classification is based on the organ primarily involved and the acute or chronic failure. The mutual impact of renal and cardiac functions makes it difficult to evaluate and manage patients with cardiorenal syndromes and worsen morbidity and mortality. This review seeks to discuss the place of biomarkers in diagnosis, management and follow-up of patients with cardiorenal syndromes. Biomarkers can be classified as functional (creatinine, cystatin C. . .) or lesional (neutrophil gelatinase-associated lipocalin, urinary cystatin C. . .) renal markers and functional (natriuretic peptides. . .) or lesional (troponin, fatty acid binding pro409 Pour citer cet article : Kuster N, Moréna M, Bargnoux AS, Leray H, Chenine L, Dupuy AM, Canaud B, Cristol JP. Biomarqueurs du syndrome cardiorénal. Ann Biol Clin 2013 ; 71(4) : 409-18 doi:10.1684/abc.2013.0877 rticle reçu le 24 décembre 2012, ccepté le 05 avril 2013 tein) cardiac markers. A last kind of biomarkers reflects the dialogue between heart and kidney (renin-angiotensin-aldosteron-system, indicators of activation of arginine vasopressin system) or the systemic impact (inflammation, oxidative stress. . .). In order to evaluate accurately the complex interactions that are the basis of cardiorenal syndromes, a multi-marker approach seems nowadays necessary.