A randomized, double-blind, placebo-controlled trial of a selective, oral sphingosine 1-phosphate (s1p) receptor modulator, etrasimod (apd334), in moderate to severe ulcerative colitis

1: Sandborn et al. William Sandborn: Abbvie – Consultant, Grant/Research Support, Speaker's Bureau. Akros Pharma – Consultant. Allergan – Consultant. Ambrx Inc. – Consultant. Amgen – Consultant, Grant/Research Support. Ardelyx – Consultant. Arena Pharmaceuticals – Consultant. Atlantic Healthcare Limited – Grant/Research Support. Atlantic Pharmaceuticals – Consultant. Avaxia – Consultant. Biogen – Consultant. Boehringer Ingelheim – Consultant. Bristol Meyers Squibb – Consultant. Celgene – Consultant. Celgene/Receptos – Grant/Research Support. Conatus – Consultant. Cosmo Technologies – Consultant. Escalier Biosciences – Consultant, Stockholder/Ownership Interest (excluding diversified mutual funds). Ferring – Consultant. Ferring Research Institute – Consultant. Forward Pharma – Consultant. Galapagos – Consultant. Genentech – Consultant, Grant/Research Support. Gilead Sciences – Consultant, Grant/Research Support. Immune Pharmaceuticals – Consultant. Index Pharmaceuticals – Consultant. Janssen – Consultant, Grant/Research Support, Speaker's Bureau. Kyowa Hakko Kirin Pharma – Consultant. Lilly – Consultant, Grant/Research Support. MedImmune – Consultant. Mesoblast – Consultant. Miraca Life Sciences – Consultant. Nivalis Therapeutics – Consultant. Novartis – Consultant. Nutrition Science Partners – Consultant. Oppilan Pharma – Consultant, Stockholder/Ownership Interest (excluding diversified mutual funds). Otsuka – Consultant. Palatin – Consultant. Paul Hastings – Consultant. Pfizer – Consultant. Precision IBD – Consultant, Stockholder/Ownership Interest (excluding diversified mutual funds). Progenity – Consultant, Stockholder/Ownership Interest (excluding diversified mutual funds). Prometheus Laboratories – Consultant. Qu Biologics – Consultant. Regeneron – Consultant. Ritter Pharmaceuticals – Consultant, Stockholder/Ownership Interest (excluding diversified mutual funds). Robarts Clinical Trials (owned by the University of Western Ontario) – Consultant. Salix – Consultant. Seattle Genetics – Consultant. Seres Therapeutics – Consultant. Shire – Consultant. Sigmoid Biotechnologies – Consultant. Takeda – Consultant, Grant/Research Support, Speaker's Bureau. Theradiag – Consultant. Theravance – Consultant. Tigenix – Consultant. Tillotts Pharma – Consultant. UCB Pharma – Consultant. Vascular Biogenics – Consultant. Vivelix – Consultant. Laurent Peyrin-Biroulet: AbbVie – Consultant, Grant/Research Support, Lecture Fees . Biogen – Lecture Fees. Boehringer Ingelheim – Consultant. Celgene – Consultant. Genentech – Consultant. GlaxoSmithKline – Consultant. Janssen – Consultant, Lecture Fees. Merck Sharp & Dohme – Consultant, Grant/Research Support, Lecture Fees . Oppilan – Consultant. Pfizer – Consultant, Lecture Fees. Roche – Consultant. Shire – Consultant, Lecture Fees. Takeda – Consultant, Grant/Research Support, Lecture Fees. Theravance – Consultant. TiGenix – Consultant. Luba Trokan: Arena – Employee. Jinkun Zhang: Arena – Employee. Tanja Kühbacher indicated no relevant financial relationships. Michael Chiorean: AbbVie – Speaker's Bureau. Arena – Advisory Committee/Board Member. Janssen – Speaker's Bureau. Medtronic – Speaker's Bureau. Pfizer – Advisory Committee/Board Member, Consultant. Salix – Consultant. Takeda – Grant/Research Support, Speaker's Bureau. Scott Lee: AbbVie Pharmaceuticals – Grant/Research Support. Arena Pharmaceuticals – Grant/Research Support. Atlantic Pharmaceuticals, Ltd. – Grant/Research Support. Celgene Pharmaceuticals, Inc. – Grant/Research Support. Cornerstones Health – Advisory Committee/Board Member, Consultant. Eli Lilly and Company – Advisory Committee/Board Member, Consultant. Janssen Pharmaceuticals, Inc. – Advisory Committee/Board Member, Consultant, Grant/Research Support. Pfizer Pharmaceuticals – Advisory Committee/Board Member, Consultant. Salix Pharmaceuticals – Grant/Research Support. Shield Therapeutics PLC – Grant/Research Support. Takeda Pharmaceuticals, Inc. – Grant/Research Support. Tetherex Pharmaceuticals – Grant/Research Support. UCB Pharma – Advisory Committee/Board Member, Consultant, Grant/Research Support. Severine Vermeire: Abbvie – Consultant, Grant/Research Support. Biogen – Consultant. Celgene – Consultant. Ferring Pharmaceuticals – Consultant. Galagapos – Consultant. Gilead – Consultant. Hospira – Consultant. Janssen – Consultant, Grant/Research Support. Merck – Grant/Research Support. Pfizer – Consultant, Grant/Research Support. Second Genome – Consultant. Takeda – Consultant, Grant/Research Support. Bruce Yacyshyn: Merck – Grant/Research Support. Snehal Naik: Arena – Employee. Preston Klassen: Arena – Employee. Julian Panes: AbbVie – Consultant, Grant/Research Support, Lecture Fees. Biogen – Lecture Fees. Boehringer Ingelheim – Consultant. Celgene – Consultant. Genentech – Consultant. Janssen – Consultant, Lecture Fees. Merck Sharp & Dohme – Consultant, Grant/Research Support, Lecture Fees. Oppilan – Consultant. Pfizer – Consultant, Lecture Fees. Roche – Consultant. Shire – Consultant, Lecture Fees. Takeda – Consultant, Lecture Fees. Theravance – Consultant. TiGenix – Consultant. Abstract 2: Sands et al. Bruce E. Sands: Consultant – 4D Pharma, AbbVie, Allergan, Amgen, Arena Pharmaceuticals, Boehringer-Ingelheim, Capella Biosciences, Celltrion Healthcare, EnGene, Ferring, Gilead, Lyndra, Oppilan Pharma, Otsuka, Palatin Technologies, Progenity, Protagonist Therapeutics, Rheos Medicines, Seres Therapeutics, Sienna Biopharmaceuticals, Takeda, Theravance Pharmaceuticals, Vivelix Pharmaceuticals. Advisory Committee/Board Member – Celgene, Janssen, Lilly, MedImmune, Millennium Pharmaceuticals, Pfizer. Grant/Research Support – Janssen, Takeda. William J. Sandborn: Consultant – Abbvie, Akros Pharma, Allergan, Ambrx Inc., Amgen, Ardelyx, Arena Pharmaceuticals, Atlantic Pharmaceuticals, Avaxia, Biogen, Boehringer Ingelheim, Bristol Meyers Squibb, Celgene, Conatus, Cosmo Technologies, Escalier Biosciences, Ferring, Ferring Research Institute, Forward Pharma, Galapagos, Genentech, Gilead Sciences, Immune Pharmaceuticals, Index Pharmaceuticals, Janssen, Kyowa Hakko Kirin Pharma, Lilly, Medimmune, Mesoblast, Miraca Life Sciences, Nivalis Therapeutics, Novartis, Nutrition Science Partners, Oppilan Pharma, Otsuka, Palatin, Paul Hastings, Pfizer, Precision IBD, Progenity, Prometheus Laboratories, Qu Biologics, Regeneron, Ritter Pharmaceuticals, Robarts Clinical Trials (owned by Health Academic Research Trust or HART), Salix, Seattle Genetics, Seres Therapeutics, Shire, Sigmoid Biotechnologies, Takeda, Theradiag, Theravance, Tigenix, Tillotts Pharma, UCB Pharma, Vascular Biogenics, Vivelix. Grant/Research Support – Atlantic Healthcare Limited, Amgen, Genentech, Gilead Sciences, Abbvie, Janssen, Takeda, Lilly, Celgene/Receptos. Speakers Bureau – Abbvie, Janssen, Takeda. Stockholder/Ownership Interest (excluding diversified mutual funds) – Escalier Biosciences, Oppilan Pharma, Precision IBD, Progenity, Ritter Pharmaceuticals. Remo Panaccione: Consultant – AbbVie, Allergan, Amgen, Boehringer-Ingelheim, Bristol-Myers Squibb, Celgene, ChemoCentryx, CoMentis, Cosmo Technologies, Coronado Biosciences, Eisai Medical Research, Elan, EnGene, Eli Lilly, Ferring, Genentech, Genzyme, Gilead, Given Imaging, GlaxoSmithKline, Human Genome Sciences, Janssen, Merck & Co., Merck Research Laboratories, MerckSerono, Millennium, Novo Nordisk, Pfizer, Procter and Gamble, Prometheus Laboratories, Receptos, Salix, Santarus, Shire Pharmaceuticals, Sigmoid Pharma, Sirtris (a GSK company), Takeda, Therakos, Theradvance, and Tillotts. Advisory Committee/Board Member – Abbvie, Abbott, Allergan, Amgen, Aptalis, AstraZeneca, Baxter, Biogen Idec, Celgene, Eisai, Ferring, Genentech, Janssen, Merck, Shire, Elan, Glaxo-Smith Kline, Hospira, Pfizer, Bristol-Myers Squibb, Takeda, Cubist, Salix. Speakers Bureau – Abbvie, Aptalis, AstraZeneca, Celgene, Ferring, Janssen, Merck, Pfizer, Prometheus, Sandoz, Shire, and Takeda. Grant/Research Support – Abbvie, Ferring, Janssen, Shire, Takeda. Christopher D. O’Brien: Employee – Janssen Research & Development, LLC. Hongyan Zhang: Employee – Janssen Research & Development, LLC. Jewel Johanns: Employee – Janssen Research & Development, LLC. Laurent Peyrin-Biroulet: Advisory Committee/Board Member – Abbvie, Janssen, Msd, Genentech, Takeda, Celltrion, Biogen, Amgen, Pfizer, Lilly, Tillots, Ferring, Arena, Index. Consultant – Abbvie, Janssen, Msd, Genentech, Takeda, Celltrion, Biogen, Amgen, Pfizer, Lilly, Tillots, Ferring, Arena, Index. Grant/Research Support – Pfizer, Abbvie, Takeda, Merck Sharp Dohme. Gert van Assche: Consultant – Janssen Research & Development, LLC. Advisory Committee/Board Member – Janssen Research & Development, LLC. Grant/Research Support – Janssen Research & Development, LLC. Silvio Danese: Speakers Bureau – AbbVie, Allergan, Biogen, Boehringer Ingelheim, Celgene, Celltrion, Ferring, Hospira, Janssen Johnson & Johnson, Merck, MSD, Takeda, Mundipharma, Pfizer, Sandoz, Tigenix, UCB Pharma, Vifor. Consultant – AbbVie, Allergan, Biogen, Boehringer Ingelheim, Celgene, Celltrion, Ferring, Hospira, Janssen Johnson & Johnson, Merck, MSD, Takeda, Mundipharma, Pfizer, Sandoz, Tigenix, UCB Pharma, Vifor. Advisory Committee/Board Member – AbbVie, Allergan, Biogen, Boehringer Ingelheim, Celgene, Celltrion, Ferring, Hospira, Janssen Johnson & Johnson, Merck, MSD, Takeda, Mundipharma, Pfizer, Sandoz, Tigenix, UCB Pharma, Vifor. Stephan Targan: Consultant – Janssen, Precision IBD Inc. (co-founder). Advisory Committee/Board Member – Symbiotix. Maria T. Abreu: Consultant – Prometheus Laboratories, Takeda, UCB, Inc., Pfizer, Janssen, Focus Medical Communications, Eli Lilly Pharmaceuticals, Theravance Biopharma Us, Inc. Advisory Committee/Board Member – Abbvie Laboratories, Celgene Corporation, Shire Pharmaceuticals, Roche Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals, AMGEN ABP 710 Biosimilar Infliximab, Allergam Brazikumab, SERES, Nestle Health Science, GILEAD. Spe