Serum Thyroid Hormone Levels in Sudanese Patients with Liver Cirrhosis

Background: There are clinical and laboratory associations between thyroid and liver diseases. Patients with chronic liver disease such as cirrhosis may have thyroiditis, hyperthyroidism, or hypothyroidism, because thyroid hormones (THs), particularly triiodothyronine (T3), are potent regulators of multiple physiological activities. The goal of the study is to assess the relationship and interconnection between thyroid hormones, and liver cirrhosis patients. Objectives: A case control study was conducted at Ibn Sena Specialist hospital in Khartoum state, Sudan, during the period of February June 2016. Participants (N/80) were divided into two groups; patient group (N/40) between the ages of 20-80 years old diagnosed as cirrhosis patients based on their medical record and without any history of without any other chronic condition, controls known as healthy subjects group (N/40). Results: in comparison with the controls, patient withcirrhosis had significantly lower levels of T3Mean= [1.7685] ±SD (.52121),P=0.01, thancontrols [2.0220] ± (.31430), while TSH, [1.8993] ± (1.01434) vs. 1.8993±1.01434 for controls, P=0.556, andT4 [105.3340] ± (40.22112) vs.160.3480±224.51627 for controls=0.131)were in significantly changed. Conclusion: The current study revealed a significant decrease level of T3 and an in significant change in TSH and T4levels than control groups.