’ s response to reviews Title : A computational method to quantitatively measure pediatric drug safety using Electronic Medical Records

Title: A computational method to quantitatively measure pediatric drug safety using Electronic Medical Records Authors: Gang Yu (yugbme@zju.edu.cn) Xian Zeng (xian_zeng@zju.edu.cn) Shaoqing Ni (chgcp@zju.edu.cn) Zheng Jia (zjia@zju.edu.cn) Weihong Chen (whhchen@sina.cn) Xudong Lu (lvxd@zju.edu.cn) Jiye An (an_jiye@zju.edu.cn) Huilong Duan (duanhl@zju.edu.cn) Qiang Shu (shuqiang@zju.edu.cn) Haomin Li (hmli@zju.edu.cn) Version: 2 Date: 09 Dec 2019 Author’s response to reviews: Firstly, we would like to thank all the editors and reviewers for their thoughtful review of the manuscript and giving us this opportunity to improve this manuscript better. These comments are all valuable and helpful for improving our article. We agree with almost all their comments and have revised our manuscript accordingly. We respond below in detail to each of the comments and questions.