Effect of Methanol Extract of Arcangelisia flava ( L . ) in High-fat diet-induced Hyperlipidemic Mice

Arcangelisia flava is one of the plants used as traditional medicine to treat hypercholesterolemia.The aim of this study. To determine the effect of anti-hypercholesterolemia extract of Arcangelisia flava In male mice induced by fat diet. This study used plant of akar kayu kuning extracted macerated with methanol solvent and tested on 24 male mice divided into 6 groups, ie treatment control dose 9,5 mg / 20gBB, 19 mg / 20gBB, 38 mg / 20gBB positive control, Negative control, and normal control with each group consisting of 5 mice. Induction of fatty feed is administered orally with quail egg yolks. Measurement of total cholesterol level was done 3 times, the measurement of early cholesterol (H0), cholesterol after induced fat feed (H7) and cholesterol after treatment (H15). Total cholesterol levels were measured by GCU test. The results of statistical analysis of the study showed that arcangelisia flava extract at 9.5 mg / 20gBB, 19 mg / 20gBB, 38 mg / 20gBB decreased total cholesterol by 10%, 13%, 17%, respectively That extract dose of 38 mg / 20gBB gives the effect of decreasing total cholesterol total thebiggest, but still different from simvastatin.