The Topographical Distribution Of White Matter Damage In Parkinson'S Disease And Progressive Supranuclear Palsy

Introduction. Progressive supranuclear palsy (PSP) is the second most common cause of neurodegenerativeparkinsonism after idiopathic Parkinson’s disease (PD) [1]. A different ante-mortem distribution of white matter (WM) damage may exist in PD and PSP patients, which might be helpful in the diagnostic work-up of these patients [2]. In this study, we investigated microstructural changes of WM in patients with PD and different PSP syndromes using tract-based spatial statistics (TBSS).