Tetrahydroquinolines and Isoxazoles : Nitrogen heterocycles as potential antibacterial agents

Nitrogen heterocycles are a part of a special group f organic substances found in many biologically a ctive natural and synthetic products with properties pharmacologi cally relevant. The synthesis and spectroscopic characterization of tetrahydroquinolines (THQs) and isoxazole are shown. These compounds were evaluate d for their in vitro antibacterial activity against Esche richia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter baumannii. With the purpose of evalua te the structural features in the antibacterial act ivity, in the present work, some substituents such as: methyl, me thoxy and hydrogen in different positions on the TH Q ring are reported.