Cloning and characterization of dominant negative splice variants of the human histamine H 4 receptor

Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor Richard M. VAN RIJN*1, André VAN MARLE*2, Paul L. CHAZOT†, Ellen LANGEMEIJER*, Yongjun QIN‡, Fiona C. SHENTON†, Herman D. LIM*, Obbe P. ZUIDERVELD*, Kamonchanok SANSUK*, Michel DY§, Martine J. SMIT*, Cornelis P. TENSEN‡, Remko A. BAKKER*3 and Rob LEURS*4 *Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands, †Centre for Integrative Neuroscience (CINS), School of Biological and Biomedical Sciences, Durham University, South Road, Durham DH1 3LE, U.K., ‡Leiden University Medical Center, Skin Research Lab, Einthovenweg 20, 2300 RC Leiden, The Netherlands, and §UMR 8147, Centre National de la Recherche Scientifique, Faculte de Medecine Rene Descartes, Paris V, Hopital Necker, 75015 Paris, France