Effect of local ozone treatment on inflammatory cytokine , growth cytokine and apoptosis molecule expression in anal fistula wound

Anal fistula is a clinical common rectum and anus disease, the main cause is that the rectal bacteria invade the anal sinuses and cause infection, and surgical treatment is needed. The wound after anal fistula surgery is special, local wound pollution is serious because of the special physiological function of daily defecation of anus, the healing process is accompanied by repair and pollution, and it's easy to cause delay in wound repair and healing[1,2]. Ozone is the means for complex wound treatment in recent years, which has strong oxidizing property, can not only kill pathogens and induce fibroblast proliferation, but can also adjust the function of endothelial cells and macrophages, and plays a significant role in promoting repair of wound[3,4]. The wound healing process involves inflammatory response, cell growth and tissue reconstruction, and various cytokines and apoptotic molecules are involved in regulating the process. In the following study, in order to define the value of ozone for the treatment of anal fistula wound, the effect of local ozone therapy on inflammatory cytokine, growth cytokine and apoptosis molecule expression in anal fistula wound was analyzed in detail.