Synthesis and Absolute Configuration a Sesquiterpene-substituted Orsellinic as a Fungal Metabolitet of Hongoquercin B , A id Isolated

In 1998, Roll et aL isolated (+)-hongoquercin B together with (+ )-hongoquercin A from an unidentified terrestrial fungus as a metabolite which was slightly active against vancomycin-resistant Enterococcusfaecium.i) Their extensive NMR study on hongoquercin B enabled them to propose structure 1 for it, although its absolute configuration remained unknown. We have recently synthesized (+)-hongoquercin A and determined its absolute configuration