The influence and clinical effect of Dl-3-butylphthalide on cerebral blood perfusion images in patients with acute ischemic stroke

Objective To observe the influence and clinical effect of Dl-3-butylphthalide on cerebral blood perfusion images in patients with artery stenosis or occlusion acute ischemic stroke. Methods 45 patients with artery stenosis or occlusion acute ischemic stroke were divided into control group (24 cases) and treatment group (21 cases) randomly, all the 45 patients were given standard treatment, and patients in treatment group were given Dl-3-butylphthalide soft capsules besides standard treatment. NIHSS, MMSE, serum hs-CRP and Hcy concentration and cerebral computed tomography perfusion were observed one month before and after treatment. Results 1.After one month of treatment, serum hs-CRP and Hcy concentration in treatment group decreased significantly compared with the control group (P< 0.05); 2. NIHSS and MMSE in treatment group improved significantly compared with the control group (P< 0.05); 3. regional cerebral blood flow (rCBF) of cerebral perfusion imaging in infarction center region increased significantly compared with prior treatment, and the growth rate was larger than the control group (P< 0.05), rCBF、rCBV of cerebral perfusion imaging in infarction ischemic penumbra region increased significantly compared with prior treatment, and the growth rate was larger than the control group. Conclusion The clinical effect of Dl-3-butylphthalide in patients with acute ischemic stroke is definite, Dl-3-butylphthalide improves the cerebral blood perfusion imaging in infarction center and ischemic penumbra region effectively, the improvement is much better in infarction ischemic penumbra region in the form of significant increase of rCBF and rCBV value. [ZHANG Ping, ZHU Bin, YAN Hai-qing, GUI Yong-kun, NIU Xiao-lu, LI Tong. The influence and clinical effect of Dl-3-butylphthalide on cerebral blood perfusion images in patients with acute ischemic stroke. Life Sci J 2014; 11(8):688-693]. (ISSN: 1097-8135). http://www.lifesciencesite.com. 100