Relationship between serum levels of Fibronectin, Leptin and hs- CRP with extension of Coronary Artery Disease

Endothelial dysfunction ,obesity and inflamation are cooperative event involved in atherosclerosis development.In the present study the serum levels of Fibronectin, Leptin, hs-CRP and lipid profile were investigated in patients of Coronary Artery Disease with control group. In This study we messured serum leveles of Fibronectin, Leptin and hs-CRP on 180 person include 160 patient with CAD and 20 individaul as control group ,also patient with malignancy, renal and liver disease and other disease were exclude from the study. The seum levels of Fibronectin, Leptin and hs-CRP were increased significantly as compared to control group (p=<0.05 in all cases).There was strong(+)correlation between Fibronectin, Leptin and hs-CRP. It was concluded that endothelial dysfunction ,obesity and inflamation are cooperative event involved in atherosclerosis development.