CARDIOVASCULAR RISK , FERRITIN AND INFLAMMATORY MARKERS IN HIV-SEROPOSITIVE PATIENTS WITH LIPODYSTROPHY Taila

Background & Aims: HIV-seropositive subjects are more susceptible to cardiovascular diseases. Thus, the objective of the present study was to determine the metabolic changes influenced by HIV infection and its treatment and the cardiovascular risk associated with ferritin and inflammatory markers. Methods: A cross-sectional study was conducted on 36 adult volunteers of both sexes divided into the following groups: HIV with lipodystrophy (HIVLIPO), HIV without lipodystrophy (HIVLIPO) and HIV (Control). Anthropometric evaluation was performed and the following analyses were carried out: glycemia, insulin, total cholesterol, LDL-C, HDL-C, triglycerides, iron, ferritin, AST, ALT, alkaline phosphatase, TNF-α and CRP. The Framingham score was calculated and HOMA-IR was determined. Results: The HIVLIPO group had higher values of HOMA-IR, glycemia, insulin, TNF-α, ferritin and cardiovascular risk and reduced values of HDL when compared to to control group. Cardiovascular risk was positively correlated with ferritin and TNF-α and negative correlated with HDL values. 1 Department of Food and Nutrition, Faculty of Pharmaceutical Sciences, São Paulo State University “Júlio de Mesquita Filho” UNESP. 2 Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo – FMRP/USP. 3 Nutritionist of the Municipality of Ribeirão Preto. 4 Professor of the Master’s/Doctoral degree in Health Promotion University of Franca (UNIFRAN). E-mail: marina.manochio@unifran.edu.br 5 Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo – FMRP/USP. 6 Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São