Evaluation of Serum Lactate Dehydrogenase Enzyme in Different Grades of Oral Sub Mucous Fibrosis among Patients Attending a Dental College Of Western India .

Oral submucous fibrosis (OSF) is a premalignant disorder associated with the chewing of areca nut (betel nut). OSF itself causes significant morbidity and may also cause mortality, if transformed into oral squamous cell carcinoma. Our study aims to evaluate lactate dehydrogenase enzyme activity in serum of different grades of oral sub mucous fibrosis and to compare them with healthy controls and to correlate the relationship between pathogenesis of OSF and the LDH enzyme among patients attending a dental college of Western India. A cross-sectional study was conducted among 30 patients of OSF and 30 healthy controls. Oral Punch Biopsy was taken from OSF patients and venous blood samples for LDH estimation was collected from both OSF patients and healthy control. Mean serum LDH level were significantly (p-0.004) higher among cases than the control. One way ANOVA for mean serum LDH between Normal oral histology and different grades of submucous fibrosis also depicted that the serum LDH level were significantly higher among cases than controls. Increase in the mean serum LDH level was linear between different histological grades as advanced histological grades was associated with more increase in serum LDH level. Estimation of serum LDH level could be a reliable and cost effective marker to diagnose OSF (premalignant condition). KeywordsLactate dehydrogenase (LDH), Oral malignancy, Oral pathology, Oral submucosal fibrosis (OSF), Squamous cell Carcinoma (SCC). -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: 20-04-2018 Date of acceptance: 07-05-2018 -------------------------------------------------------------------------------------------------------------------------------------