Effect of Ileo-Jejunal Intestinal Adaptation Colectomy in Dogs Transposition on after Total

SASAKI, I., TUCHIYA, T., NAITO, H., FUNAYAMA, Y., TODA, M., SUZUKI, Y., SATO, T. and OHNEDA, A. Effect of Ileo-Jejunal Transponsition on Intestinal Adaptation after Total Colectomy in Dogs. Tohoku J. exp. Med., 1987, 151(4), 419-428 The effect of ileo-jejunal transposition (IJT) on the intestinal adaption after total colectomy was investigated in 4 mongrel dogs. Hyperenteroglucagonemia was observed in the IJT with colectomy group, especially in postprandial state. Obvious hyperplastic changes were observed in all part of the small intestinal mucosa in the colectomy with IJT group. However, there were no significant differences in body weight changes between the colectomy with IJT group and the colectomy group. Postprandial plasma gastrin levels were lower in the colectomy with IJT group compared to the control. These results suggest that IJT causes hyperenteroglucagonemia and intestinal mucosal hypertrophy in colectomized dogs. Enteroglucagon may have an inhibitory effect on postprandial gastrin release. ileo-jejunal transposition ; intestinal mucosal hyperplasia ; enteroglucagon ; total colectomy