substrate transport upon cooperative estradiol-17-ß-D-3 glucuronide binding in a Drosophila ABCC transporter 4 5 Short title : 6 Increased coupling by cooperative substrate binding in Drosophila ABCC

Correspondig author: 18 Flóra Szeri 19 Active Transport Proteins Research Group 20 Institute of Enzymology 21 Research Centre for Natural Sciences 22 Hungarian Academy of Sciences 23 Street address: Magyar tudósok körútja 2, H-1117, Budapest, Hungary 24 Postal address: 1519 Budapest, Pf. 286, Hungary 25 Phone: +36 306703955 26 Fax: 3613826700 27 28 Current affiliation: Department of Dermatology and Cutaneous Biology, 29 Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, 30 PA, USA 31 32 33