Effect of heparin-sodium and enoxaparin on rats tibial fracture healing : clinical , anatomopathological , and biomechanical approach

Anticoagulant agents have been increasingly used as a therapeutic measure or prophylactic treatment for thromboembolic disease in patients with fractures . When one takes into account how frequently anticoagulants are given to patients with fractures, one question arises: whether anticoagulants can adversely affect bone repair or not. Trueta and Buckwalter & Cruess stated that anticoagulants delay bone consolidation in classic texts of orthopedic and traumatology literature. Other authors also confirmed this hypothesis. Other studies, however, did not find any effect of anticoagulants upon bone fracture repair .