elators relieve copper-induced oxidative stress in vivo†

Cu selective chelators exhibit 10 times higher conditional stability constants toward Cu over Cu and other biologically relevant metal ions. The chelators specifi cally remove excess Cu ions from living cells and alleviate Cu induced oxidative stress all the way from Menkes disease model cells of Cu overload to a live multicellular vertebrate system. The unique selectivity of our chelators indicates tremendous potential in minimizing side-eff ects associated with non-specifi c Cu ion chelation based therapy currently used treat severe neurological and metabolic disorders like, Wilson’s disease, amyotrophic lateral sclerosis, and Alzheimer’s disease. As featured in: