Disruption of relationship between serotonin trans- porter and hippocampal volumes in first-episode drug-naïve major depressive disorder

s | 61 67%±13%). Functional MRI revealed decreased activation in the right inferior frontal (rIFC, pFWE-cluster=0.02) and left middle temporal gyri (lMTG, pFWE-cluster=0.03) to negative faces following citalopram infusion (for p=0.001 uncorrected on peak level). Conclusions: The newly implemented methods yielded serotonin transporter occupancy values in agreement with published data obtained using well validated procedures [1]. FMRI results are at odds with increased activity during an emotional paradigm in the lMTG following 10 days of SSRI treatment observed by our group [2]. Further, meta-analysis revealed lower activation to negative stimuli in the rIFC of depressed patients [3]. These preliminary results indicate that acute challenge with a subtherapeutic SSRI dose elicits brain activation changes distinct to those seen with prolonged treatment. It will be interesting to see what insights will arise from direct integration of molecular and functional imaging data in clinical populations.